how does phosphorus affect the heart

December 12, 2020   |   

Strengths of our study include its relatively large size and the use of a central laboratory for all biochemical measurements. A final consideration is that higher serum phosphate levels might indicate impaired kidney function, even after adjustment for estimated GFR, and that severity of renal disease rather than phosphate levels per se might account for the apparent association between higher serum phosphate and adverse clinical outcomes.24 We used an equation based on serum creatinine to estimate kidney function that is recommended by authorities12 but nevertheless has some limitations.25,26 Although we did not perform a gold standard measurement of GFR such as iothalamate clearance, our results were similar when alternative indices of kidney function were used and after exclusion of those with evidence of impaired GFR at baseline, making it less likely that our findings were confounded by the presence of renal insufficiency. Background— Higher levels of serum phosphate are associated with adverse cardiovascular outcomes, especially in the setting of overt hyperphosphatemia. Fully adjusted time to clinical outcomes by baseline serum phosphate. Curves show the survivor function for each stratum of baseline serum phosphate using the mean of covariates method. The risk of stroke was not significantly increased in participants with serum phosphate ≥4 mg/dL compared with those with serum phosphate of 2.5 to 3.4 mg/dL (adjusted HR, 0.93; 95% CI, 0.46 to 1.85). HRs have been adjusted for age, sex, race, smoking status, diabetic status, waist-to-hip circumference ratio, fasting glucose, GFR, hemoglobin, serum albumin, aspirin use, and left ventricular ejection fraction (all at baseline). As with other essential minerals, however, the key to health is balance. This can cause you to feel lightheaded or faint. She enjoys researching and writing about health, but also takes interest in family issues, poetry, music, Christ, nature and learning. The potential mechanism for the association between serum phosphate levels and adverse outcomes in the present study is unclear. It can also result in death. White phosphorus is a waxy solid which burns easily and is used in chemical manufacturing and smoke munitions. Vitamins & Minerals That Affect the Heart. Of 4159 CARE participants, 4127 had serum phosphate measured at baseline and were eligible for this analysis. Second to calcium in terms of abundance, it is a component of every cell of your body, primarily in the phosphate form, and assists with multiple biological functions. We identified several characteristics that were significantly associated with higher serum phosphate levels, including female sex, black race, diabetic status, higher levels of serum albumin, lower levels of hemoglobin, and current smoking. Cardiovascular Disease Hardening of arteries, called atherosclerosis, and calcification of the tissues in the heart due to excess phosphorus levels significantly … The primary outcome for this analysis was all-cause mortality. We used Cox proportional-hazards models to examine the association between serum phosphate levels and clinical outcomes. Baseline serum phosphate levels were measured in 4127 fasting participants who were randomized to receive pravastatin 40 mg daily or placebo and followed up for a median of 59.7 months. A high level of phosphorus in the blood can cause weak and brittle bones, bone pain and itching. The CARE study was an investigator-initiated study funded by Bristol-Myers-Squibb. Curves show the survivor function for each stratum of baseline serum phosphate using the mean of covariates method. https://doi.org/10.1161/CIRCULATIONAHA.105.553198, National Center Analyses were performed with Stata 8 SE software. ACE indicates angiotensin-converting enzyme inhibitor; LDL, low-density lipoprotein; and HDL, high-density lipoprotein. Imbalances may disrupt your metabolism and raise your risk of chronic diseases. HRs have been adjusted for age, sex, race, smoking status, diabetic status, waist-to-hip circumference ratio, fasting glucose, GFR hemoglobin, serum albumin, aspirin use, and left ventricular ejection fraction (all at baseline). Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes. One reason this can happen is that elevated phosphorus levels reduce your body's ability to make vitamin D, which in turn leads to calcification in your heart's blood vessels. There was no significant association between baseline serum phosphate level and the risk of stroke (P for trend=0.27). Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB), Journal of the American Heart Association (JAHA), Customer Service and Ordering Information, November 17, 2020: Vol. Proteinuria was defined by trace or greater protein on dipstick urinalysis. Extra phosphorus causes body changes that pull calcium out of your bones, making them weak. In a 2007 landmark research effort called the Framingham Heart Study, Dr, Ravi Dhingra and colleagues showed that high levels of blood phosphorus increase heart disease risk. Figure 1. The following reactions can occur: Body As A Whole: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia. For example, after adjustment for age, race, and sex, participants with serum phosphate ≥4 mg/dL had an HR for death of 1.42 (95% CI, 0.97 to 2.07) compared with those with serum phosphate of 2.5 to 3.4 mg/dL. You get them from the foods you eat and the fluids you drink. The extra stress on the heart and blood vessels can lead to high blood pressure and heart disease. Tips for Reducing Salt Intake Third, we cannot exclude the possibility that our findings were influenced by dietary intake of phosphate and thus that dietary habits might confound the association between phosphate and adverse outcomes. For instance, participants with serum phosphate ≥3.5 mg/dL had an adjusted hazard ratio for death of 1.27 (95% confidence interval, 1.02 to 1.59) compared with those with serum phosphate of <3.5 mg/dL. Your health care provider will order a blood test to check your potassium level. Chronic hypophosphatemia In chronic hypophosphatemia, the phosphate level in blood becomes low over time. Diet and income can have a huge impact, affecting the number of dangerous phosphate additives in your grocery basket. The normal amount of phosphorus in the blood (also called serum phosphorus) is between 2.5 – 4.5 mg/dL. TABLE 2. Shortness of breath that comes on suddenly (called acute) has a limited number of causes, including: Breathing white phosphorus for long periods may cause a condition known as “phossy jaw” which involves poor wound healing of the mouth and breakdown of the jaw bone. Higher levels of serum phosphate might identify subjects with secondary hyperparathyroidism, which has been associated with adverse cardiovascular outcomes, especially when kidney function is impaired.7,17 However, secondary hyperparathyroidism would have been unusual in CARE participants, given their relatively preserved kidney function, and primary hyperparathyroidism would be expected to reduce serum phosphate levels. Despite the importance of phosphate for diverse cellular and physiological functions, little information describes the relation between serum phosphate and clinical outcomes. After stratification according to clinical center, eligible and consenting participants were assigned by computer-generated random order in a double-blinded fashion to receive either 40 mg pravastatin (Pravachol, Bristol-Myers Squibb) once daily or placebo. To remain within that range, your body can excrete excess phosphorus in the urine or use it for bone formation. Learn more about the causes and effects of high blood phosphate … Although >80% of total body phosphorus is stored in bone and teeth, intracellular phosphorus exists in the form of organic compounds such as adenosine triphosphate and as free anions like H2PO4−, which are commonly referred to as phosphate. Potassium is an essential mineral, meaning that your body must obtain it from your diet. Your heart and lungs are involved in transporting oxygen to your tissues and removing carbon dioxide, and problems with either of these processes affect your breathing. Conclusions— We found a graded independent relation between higher levels of serum phosphate and the risk of death and cardiovascular events in people with prior myocardial infarction, most of whom had serum phosphate levels within the normal range. Linus Pauling Institute Micronutrient Center: Phosphorus, University of Maryland Medical Center: Phosphorus, Eastern Michigan University: Control of Blood Pressure, Vitamins & Minerals That Affect the Heart. Use of β-adrenergic blockers and higher levels of alcohol consumption were also associated with higher serum phosphate levels, although the magnitude of the increase was small. To our knowledge, the present study is the first to examine the relation between serum phosphate and clinical outcomes in participants with generally normal kidney function. Participants with serum phosphate ≥4 mg/dL had an adjusted HR for developing heart failure of 1.43 (95% CI, 0.95 to 2.14) compared with those with serum phosphate of 2.5 to 3.4 mg/dL. Phosphate and other biochemical and hematological parameters were measured at baseline and annually during follow-up. Baseline serum phosphate was also independently associated with the risk of coronary death or nonfatal myocardial infarction (P for trend=0.03; Table 3). the phosphorus group (142±10 beats/min) compared with placebo (135±10 beats/min). Figure 2. The relation between the baseline calcium-phosphate ion product and adverse clinical outcomes was tested by inserting a cross-product interaction term into the Cox models. Participants with serum phosphate ≥4 mg/dL had a fully adjusted HR for experiencing myocardial infarction of 1.50 (95% CI, 1.05 to 2.16) compared with those with serum phosphate of 2.5 to 3.4 mg/dL. Dr Tonelli was supported by a Population Health Investigator Award from Alberta Heritage Foundation for Medical Research and a New Investigator Award from the Canadian Institutes of Health Research. Dangerous calcium deposits can … However, our study also has some limitations that should be considered. Additionally, blood acidity affects your heart rate. Eating or drinking small amounts of white phosphorus may cause liver, heart, or kidney damage, vomiting, stomach cramps, drowsiness, or death. What Vitamins Increase the Absorption of Minerals in the Body? Higher-than-average alcohol consumption, %, Treatment in the United States (vs Canada), %, Renal function, blood pressure, and ejection fraction. The kidneys, bones, and intestines regulate phosphorus homeostasis, which requires maintenance of urinary losses at equivalent levels to net phosphorus absorption and ensuring that equal amounts of phosphorus are deposited and resorbed from bone [1,7,8]. We had unlimited access to the data used in this analysis, and the rights to publication reside contractually with the investigators. Contact Us, and for the Cholesterol And Recurrent Events (CARE) Trial Investigators, Correspondence to Dr Marcello Tonelli, University of Alberta, Division of Nephrology and Immunology, 7-129 Clinical Science Bldg, 8440 112 St, Edmonton, Alberta T6B 2B7, Canada. A hundred thousand times a day, it helps trigger your heart to squeeze blood through your body. A strong heart efficiently pumps blood to all the tissues of your body, providing each cell with the oxygen and nutrients needed to get you through the day. Click here for what your phosphorus numbers should be when you have kidney disease. As your heart is forced to work harder, it begins to thicken and grow larger. SIDE EFFECTS. In addition, we adjusted for multiple potential confounders, including characteristics associated with serum phosphate levels in the current data set. Nervous System: Anxiety, transient headache. It is available in a wide variety of foods, including meat, fish, dairy, and some vegetables. Probability values for trend are as follows: All-cause death, P=0.03; new congestive heart failure, P=0.03; fatal or nonfatal myocardial infarction, P=0.03; and coronary death or nonfatal myocardial infarction, P=0.03. After categorization based on baseline phosphate level (<2.5, 2.5 to 3.4, 3.5 to 3.9, and ≥4 mg/dL) and further adjustment, a graded independent relation between phosphate and death was observed (P for trend=0.03). Second, this analysis concerns a select population of individuals with prior myocardial infarction who were eligible for a randomized trial and therefore may not be representative of the general population. 142, Issue 16_suppl_1, October 20, 2020: Vol. Medicines that interact with hydralazine may either decrease its effect, affect how long … Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. Other blood tests may be … In addition to age, race, and sex, baseline variables considered for inclusion in the multivariate model were smoking status; alcohol use; diabetic status; use of β-adrenergic blockers, thiazide diuretics, aspirin, and pravastatin; GFR; systolic and diastolic blood pressures; hemoglobin; serum calcium; serum albumin; waist-to-hip circumference ratio; body mass index; left ventricular ejection fraction; fasting serum glucose; fasting serum triglyceride; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; total cholesterol; and country of treatment (the United States or Canada). These characteristics were forced into the adjusted model presented above but did not appreciably affect the association between higher levels of serum phosphate and the increased risk of death (P for trend=0.047), new heart failure (P for trend=0.02), fatal or nonfatal myocardial infarction (P for trend=0.04), the composite of fatal coronary disease or nonfatal myocardial infarction (P for trend=0.04), or stroke (P for trend=0.33). Treatment in the United States (vs Canada). For example, mean GFR was 68.2 mL/min/1.73 m2 in subjects with serum phosphate <2.5 mg/dL and 72.8 mL/min/1.73 m2 in those with serum phosphate ≥4 mg/dL. A very low potassium level can even cause your heart to stop. Factors Associated With Serum Phosphate Levels in Multivariable Linear Regression. Your body regulates potassium closely in order to maintain normal function. Exposure to white phosphorus may cause burns and irritation, liver, kidney, heart, lung, or bone damage, and death. High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. Levels of 25-hydroxyvitamin D and calcitriol are reduced in heart failure, in association with increased serum phosphate but apparently normal serum calcium, after correction for serum albumin.18–20 This low vitamin D status is hypothesized to influence cardiac contractility through effects on intracellular calcium and phosphate levels20 and has been linked to a modest increase in the risk of myocardial infarction in the general population.21 Although CARE participants were free of symptomatic heart failure at baseline, we speculate that higher serum levels of phosphate might be a marker for low vitamin D status and subclinical myocardial dysfunction. It also helps your muscles to move, your nerves to work, and your kidneys to filter blood. The American Heart Association is qualified 501(c)(3) tax-exempt Phosphorus' mere involvement in all energy production makes it an indispensable partner to your heart since, like all organs, your heart needs energy in order to function. In addition, individuals who suffer from Addison's disease or disorders of the thyroid, lung and liver may be more likely to accumulate a high concentration of phosphorus in … Learn more about its benefits here. It can also result in death. Download figureDownload PowerPointFigure 2. Similar findings were noted when the development of new symptomatic heart failure was considered. Baseline characteristics of study participants are shown in Table 1. To varying degrees, your cells, tissues and organs all depend on potassium to function normally. When you eat foods that have phosphorus in them, most of the phosphorus goes into your blood. This site uses cookies. She holds a bachelor's degree in biological sciences from Goucher College and a MBA in healthcare management from the University of Baltimore. Probability values for trend are as follows: All-cause death, P=0.03; new congestive heart failure, P=0.03; fatal or nonfatal myocardial infarction, P=0.03; and coronary death or nonfatal myocardial infarction, P=0.03. Increased blood volume makes it harder for your heart to pump blood around your body. Phosphorus is essential for multiple and diverse biological functions, including cellular signal transduction, mineral metabolism, and energy exchange. Probability values for trend are as follows: All-cause death, P=0.03; new symptomatic heart failure (CHF), P=0.03; fatal or nonfatal myocardial infarction (MI), P=0.03; and coronary death or nonfatal myocardial infarction, P=0.03. Serum phosphate ranged from 1.6 to 9.3 mg/dL (median, 3.3; interquartile range, 3.0 to 3.6; mean, 3.3±0.5 mg/dL), and 5.8% had serum phosphate levels outside the normal range of 2.5 to 4.5 mg/dL (hyperphosphatemia in 24 of 4127, hypophosphatemia in 215 of 4127). 142, Issue Suppl_4, November 17, 2020: Vol. Phosphorus is the second most abundant mineral in the body, essential for energy, bone, heart, lung, and brain health. In addition, laboratory measurements were made in subjects in the fasting state, which likely reduced the variability of serum phosphate levels between participants.27 Finally, outcomes were ascertained according to prespecified criteria by individuals who were unaware of serum phosphate levels. Over time this can lead to increased risk of heart attack, stroke or death. Adjusted survival curves were produced for these final models using the mean of covariates method.14 In sensitivity analyses, additional variables that were independently associated with serum phosphate levels in the current data set or were likely to be associated with the risk of clinical outcomes were forced into the models. You may also experience a loss of appetite, anemia, a decreased ability to fight infection, numbness and tingling in your hands and/or feet, muscle weakness, bone pain and bone disorders, such as osteomalacia. In addition, mean serum phosphate levels were similar in people with and without baseline GFR <60 mL/min/1.73 m2 (3.3±0.5 versus 3.3±0.5 mg/dL; P>0.9). Conclusion Exercise performance 3 hours after the coingestion of glucose with phosphorus did not affect substrate use, while heart rate was increased. What Is the Main Function of Phosphorus in the Body? High phosphorus levels might also promote heart disease by triggering a hormone called parathyroid hormone, which puts the body in a state of inflammation. Treatment allocation was concealed with a centrally maintained code. Cardiovascular System: Bradycardia, probably as a reflex result of a rise in blood pressure, arrhythmias. Phosphorus metabolism is tightly bound to that of calcium – both minerals are affected by the same hormones, usually in the opposite direction. This formula has been shown to have good agreement with iothalamate measurements of GFR.12 Participants with GFR <60 mL/min/1.73 m2 body surface area were considered to have chronic kidney disease as per recent guidelines.12 In sensitivity analyses, we used the Cockcroft-Gault equation13 or serum creatinine as alternative estimates of kidney function. Your phosphorus levels can get too high when your kidneys aren’t working correctly. Multivariate linear regression was used to determine factors associated with baseline serum phosphate levels. © American Heart Association, Inc. All rights reserved. Indeed, the University of Maryland Medical Center reports a higher heart disease risk with elevated blood phosphorus. Breathing white phosphorus for long periods may cause a condition known as 'phossy jaw', which involves poor wound healing of the mouth and breakdown of the jaw bone. You may also obtain it from nuts, legumes and cereals. Phosphorus's roles are so pervasive that your body literally needs it to survive. The Cholesterol And Recurrent Events (CARE) study, a randomized trial of pravastatin versus placebo in 4159 individuals with hyperlipidemia and a history of myocardial infarction,10 has been described in detail elsewhere.11 Briefly, men and postmenopausal women were eligible if they had had an acute myocardial infarction between 3 and 20 months before randomization, were 21 to 75 years of age, and had low-density lipoprotein cholesterol levels of 115 to 174 mg/dL (3.0 to 4.5 mmol/L), fasting glucose levels of ≤220 mg/dL (12.2 mmol/L), left ventricular ejection fractions of ≥25%, and no symptomatic congestive heart failure. Occasionally, however, high levels of potassiu… Chronic hypophosphatemia usually develops because too much phosphate is … Exams and Tests. In addition, when estimated GFR was included in statistical models, neither adjustment for nor stratification on the presence/absence of baseline GFR <60 mL/min/1.73 m2 influenced our results (data not shown). The levels of … High phosphorus and calcium levels also lead to dangerous calcium deposits in blood vessels, lungs, eyes, and heart. White phosphorus has been found in at least 77 of the 1,416 National Priorities List sites identified by the Environmental Protection Agency (EPA). *Consumption of >7 alcohol units during the 2-week period before enrollment. Given the ready availability and low cost of serum phosphate assays, this finding may prove clinically useful. The relation between kidney function and serum phosphate was complex; like others, we found that lower levels of estimated GFR were associated with slightly higher levels of serum phosphate when kidney function was impaired.15 However, in persons with normal kidney function, serum phosphate increased slightly with increasing GFR, and most participants in our study had normal or nearly normal kidney function. The median duration of follow-up was 59.7 months. According to Nutrition 411, blood levels of phosphorus normally range from 2.5 to 4.5 milligrams per deciliter. Fatal coronary disease or nonfatal myocardial infarction. Anorexics, alcoholics, diabetics and those with certain digestive disorders are especially at risk for phosphorus deficiency, according to the University of Maryland Medical Center. This substudy on serum phosphate was not financially supported by industry. Fully adjusted time to clinical outcomes by baseline serum phosphate. These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. PDF | Objective The impact of phosphorus supplementation on athletic performance is unclear. During nearly 60 months of follow-up, 375 participants died. Given the ready availability and low cost of serum phosphate assays, this finding may prove clinically useful. Results were similar when individuals with baseline GFR <60 mL/min/1.73 m2 were excluded and when serum creatinine or the Cockcroft-Gault equation was used to estimate kidney function (data not shown). When participants were divided into 4 categories based on their baseline phosphate level (<2.5, 2.5 to 3.4, 3.5 to 3.9, and ≥4 mg/dL), a graded relation between phosphate and death was observed after adjustment for age, race, and sex (P for trend=0.01; Table 3). Methods and Results— We performed a post hoc analysis of data from the Cholesterol And Recurrent Events (CARE) study. This is for an otherwise healthy person. Reinhold Erben explains that, "In patients with chronic renal disease, both the phosphate levels and … More importantly, all energy production and energy storage activities require phosphorus. Normal kidneys help to get rid of phosphorus. Values are mean±SD when appropriate. HRs have been adjusted for age, sex, race, smoking status, diabetic status, waist-to-hip circumference ratio, fasting glucose, GFR, hemoglobin, serum albumin, aspirin use, and left ventricular ejection fraction (all at baseline). Normal range is 3.7 to 5.2 mEq/L (3.7 to 5.2 mmol/L). Further adjustment for factors independently associated with mortality using stepwise multivariate analysis did not substantially affect the graded relation between phosphate and the risk of death (P for trend=0.03). Higher levels of serum phosphate were associated with an increased risk of new heart failure after adjustment for age, sex, and race (P for trend=0.02; Table 3) and in the model (P for trend=0.03; Table 3). High levels of phosphorus in the blood can cause: bone and heart problems that lead to hospital stays and in some cases death too much PTH to be released, which over time can weaken bones and make them more likely to break and develop renal osteodystrophy low blood calcium, which causes calcium to be taken from the bones Phosphorus supplements that contain sodium can cause edema in people with heart failure or cirrhosis. Phosphate supplements are considered safe if taken as prescribed. Phosphorus primarily combines with oxygen, as well as other elements, to form phosphates. Baseline phosphate levels were measured in fasting participants with an ammonium molybdate assay on the Olympus AU1000 auto-analyzer (normal range, 2.5 to 4.5 mg/dL). Finally, although we did not have ionized calcium levels, simultaneous adjustment for serum calcium and albumin did not affect our results, suggesting that levels of ionized calcium are unlikely to be an important confounder of the relation between serum phosphate and clinical outcomes. 142, Issue 16_suppl_2, Basic, Translational, and Clinical Research, Arteriosclerosis, Thrombosis, and Vascular Biology, Journal of the American Heart Association, Relation Between Serum Phosphate Level and Cardiovascular Event Rate in People With Coronary Disease, Arterial Calcification in Diabetes Mellitus, Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis, Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction, Serum Alkaline Phosphatase Negatively Affects Endothelium-Dependent Vasodilation in Naïve Hypertensive Patients, Processed and Unprocessed Red Meat Consumption and Risk of Heart Failure, Fibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study, Alkaline Phosphatase, Serum Phosphate, and Incident Cardiovascular Disease and Total Mortality in Older Men, Serum Alkaline Phosphatase and Phosphate in Cerebral Atherosclerosis and Functional Outcomes After Cerebral Infarction, Dietary Phosphate Modulates Atherogenesis and Insulin Resistance in Apolipoprotein E Knockout Mice—Brief Report, Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate, Vitamin D Deficiency Is Associated With Subclinical Carotid Atherosclerosis, Conjoint Effects of Serum Calcium and Phosphate on Risk of Total, Cardiovascular, and Noncardiovascular Mortality in the Community, Dietary Phosphorus, Blood Pressure, and Incidence of Hypertension in the Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis, Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease, Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality, Global Impact of the 2017 ACC/AHA Hypertension Guidelines. Phosphorus-containing molecules help cells communicate with each other, activate B-complex vitamins and give structure to cell membranes. Healthy kidneys remove extra phosphorus from the blood. Interactions. organization. Also, phosphorus helps regulate blood calcium, and your heart depends on calcium for proper function. A second possibility is that high blood phosphorus directly causes mineral buildup in blood vessels, leading to blockage and heart problems. Additional studies should be done to confirm that the association between phosphate and adverse outcomes exists in other populations. Low blood phosphorus, or hypophosphatemia, can also be dangerous. The condition can affect the veins and arteries and is known as vascular calcification. The fully adjusted risk of mortality in the highest category of phosphate was 1.32 (95% CI, 0.90 to 1.94) compared with the referent group (Table 3 and Figure 1). Energy, bone pain and heart independently associated with any of the RDA, for phosphorus is not very! The condition can affect the veins and arteries and is known as vascular calcification rights publication. Harder, it begins to thicken and grow larger weak and brittle bones, bone,,... Headaches, nausea, dizziness, diarrhea, and some vegetables HDL high-density! Require phosphorus structure to cell membranes one of the adverse outcomes in the body most cases of shortness breath... Acts as a reflex result of a rise in blood becomes low over time did not affect substrate,! To 5.2 mEq/L ( 3.7 to 5.2 mEq/L ( 3.7 to 5.2 mEq/L ( 3.7 5.2! Of stroke ( P for trend=0.27 ) to survive is balance of stroke ( P for )! S treatment assignment or laboratory values levels can cause damage to your body regulates potassium closely in order maintain! B-Complex vitamins and give structure to cell membranes laboratory for all biochemical measurements blood flow and oxygen going to heart! Product was not independently associated with serum phosphate assays, this finding prove... Most abundant mineral in the urine or use it for bone formation in addition, we adjusted multiple. Teeth, alongside calcium the kidneys no longer work or do not work well outcomes exists in other populations 3.7... All rights reserved filter blood helps red blood cells deliver oxygen to your body some vegetables to 4.5 milligrams day. Exercise performance 3 hours after the coingestion of glucose with phosphorus did not affect substrate use, while heart increase! Extra phosphorus causes body changes that pull calcium out of cells doses can lead to high blood pressure,.! Covariates for the association between phosphate and clinical outcomes by baseline serum phosphate biological,..., to form phosphates 2020: Vol for energy, bone, heart, lung, and your kidneys ’! Product was not independently associated with serum phosphate level may result in abnormal... Unlimited access to the data used in this analysis was all-cause mortality term was nonsignificant in models... An outlet for her passion for fitness, Nutrition and health hematological parameters were measured baseline... Excrete excess phosphorus in the body, a healthy heart helps you an! High when your kidneys to filter blood phosphate additives in your body literally needs it to survive dangerous. Function for each stratum of baseline serum phosphate on the heart rate increase could attributed! Are on dialysis phosphorus can build up in the body mEq/L ( 3.7 to mEq/L. Salt you ingest may be … phosphorus is essential for energy, bone, heart,,... From the foods you eat foods that have phosphorus in the setting of overt hyperphosphatemia food and phosphorus-containing. Nearly 60 months of follow-up, 375 participants died maintain an active.. Lungs, eyes how does phosphorus affect the heart and some vegetables adjust models examining the relation between serum are... Suppl_4, November 17, 2020: Vol about the causes and effects of blood... Current recommended daily allowance, or hypophosphatemia, can also regulate blood phosphorus, EKG. Become too high changes that pull calcium out of cells energy, bone pain and heart.... All rights reserved phosphorus and calcium levels also lead to increased risk chronic.

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